Ceramide Pathway

Description:

The SM (Sphingomyelin) pathway is an evolutionarily conserved stress response system linking diverse environmental stresses (Ultraviolet, Heat Shock, Oxidative Stress, and Ionizing Radiation) to cellular effector pathways. Ceramide is the second messenger in this system and can be generated either by hydrolysis of SM through SM-specific PLC (Phospholipase-C) termed SMases (Sphingomyelinases) or by de novo synthesis through the enzyme Ceramide Synthase . There are two classes of SMase, acidic (A-Smase) and neutral (N-Smase). Stre...

References:

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.
Yabu T, Shiba H, Shibasaki Y, Nakanishi T, Imamura S, Touhata K, Yamashita M.
Cell Death Differ. 2015 Feb;22(2):258-73. doi: 10.1038/cdd.2014.128. Epub 2014 Aug 29.
Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.
Czubowicz K, Strosznajder R.
Mol Neurobiol. 2014 Aug;50(1):26-37. doi: 10.1007/s12035-013-8606-4. Epub 2014 Jan 14.
Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate.
Ueda N.
Int J Mol Sci. 2015 Mar 5;16(3):5076-124. doi: 10.3390/ijms16035076. Review.
Sphingolipid metabolic pathway: an overview of major roles played in human diseases.
Pralhada Rao R, Vaidyanathan N, Rengasamy M, Mammen Oommen A, Somaiya N, Jagannath MR.
J Lipids. 2013;2013:178910. doi: 10.1155/2013/178910. Epub 2013 Aug 4.

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Pathways

Ceramide Pathway

Description:

References:

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.

Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.

Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate.

Sphingolipid metabolic pathway: an overview of major roles played in human diseases.

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Pathways

Ceramide Pathway

Description:

References:

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.

Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.

Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate.

Sphingolipid metabolic pathway: an overview of major roles played in human diseases.

Databases

Tools

Institutional License

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