Pathways
Checkpoint Signaling in Yeast
Description:
The maintenance of genomic integrity is important for the survival of eukaryotic cells. Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. Various forms of DNA damage and various treatments that block replication trigger these checkpoints. Checkpoint pathways and proteins are evolutionarily conserved from yeast to man, underlining their importance in maintaining genomic integrity. In the fission yeast, S. pombe (Schizosaccharomyces pombe), ...
References:
-
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. -
Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3676-85. doi: 10.1073/pnas.1525620113. Epub 2016 Jun 13. -
Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
PLoS One. 2015 Jul 1;10(7):e0130748. doi: 10.1371/journal.pone.0130748. -
Induction of a G1-S checkpoint in fission yeast.
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9911-6. doi: 10.1073/pnas.1204901109. Epub 2012 Jun 4.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions