Chemokines are chemotactic cytokines belonging to a large family of small, secreted proteins that stimulate the cells migration and the positioning and interactions of cells within tissue. About 50 endogeneous chemokine ligands and 20 cell surface G protein-coupled heptahelicalchemokine receptors together form the chemokine superfamily. Chemokines regulate leukocyte migration into the tumor microenvironment and thus play import[...]
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