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Chemokine Signaling


Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. Initially chemokines were divided into groups based on having chemotactic or homeostatic function, but several dual-function chemokines have since been described. To date, 44 chemokines and 23 chemokine receptors have been identified i[...]




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