CHKs in Checkpoint Regulation

Description:

The DNA damage response network involves several kinases to inactivate CDK/ cyclin complexes and result in cell cycle arrest for DNA repair. In the presence of DNA damage or incomplete DNA replication, eukaryotic cells activate cell cycle checkpoints that temporarily halt the cell cycle to permit DNA repair or completion of DNA replication to take place. In the presence of extensive damage or absence of timely repair, these checkpoint-signaling pathways may also trigger a pathway that effects programmed cell death or apoptosi...

References:

Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27phosphorylation, and cell cycle: role and targeting.
Gurgis FM, Ziaziaris W, Munoz L.
Mol Pharmacol. 2014 Feb; 85(2):345-56. doi: 10.1124/mol.113.090365. Epub 2013 Dec 2. Review.
Chk1 and Chk2 kinases in checkpoint control and cancer.
Bartek J, Lukas J.
Cancer Cell. 2003 May; 3(5):421-9. Review.
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, Kanai F, Zhou BB, Chung JH, Rathbun GA.
J Biol Chem. 2002 May 3; 277(18):16102-15. Epub 2002 Jan 30. Erratum in: J Biol Chem 2002 Sep 20; 277(38):35776-7.
The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.
Shaltiel IA, Krenning L, Bruinsma W, Medema RH.
J Cell Sci. 2015 Feb 15; 128(4):607-20. doi: 10.1242/jcs.163766. Epub 2015 Jan 20. Review.

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Pathways

CHKs in Checkpoint Regulation

Description:

References:

Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27phosphorylation, and cell cycle: role and targeting.

Chk1 and Chk2 kinases in checkpoint control and cancer.

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.

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Tools

Institutional License

Pathways

CHKs in Checkpoint Regulation

Description:

References:

Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27phosphorylation, and cell cycle: role and targeting.

Chk1 and Chk2 kinases in checkpoint control and cancer.

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.

Databases

Tools

Institutional License

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