Pathways
CHREBP Regulation in Pancreatic B cell
Description:
CHREBP (Carbohydrate-response element-binding protein) is the major transcription factor conferring glucose-induced gene expression in pancreatic islets, liver and adipose tissue. To date, only two natural isoforms, CHREBPα and CHREBPβ, have been identified. CHREBP-β was identified in adipose tissue and found to be also expressed in islets and involved in glucose-induced beta cell proliferation. In adult pancreatic β cells, CHREBP activity is regulated by its cytosolic/nuclear localization ...
References:
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ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line.
PLoS One. 2016 Jan 25;11(1):e0147411. doi: 10.1371/journal.pone.0147411. eCollection 2016. -
Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop.
Mol Metab. 2016 Sep 30;5(12):1208-1215. doi: 10.1016/j.molmet.2016.09.010. eCollection 2016 Dec. -
Novel insights into ChREBP regulation and function.
Cell Metab. 2017 Aug 1;26(2):324-341. doi: 10.1016/j.cmet.2017.07.004. Review. -
Sweet Sixteenth for ChREBP: Established Roles and Future Goals.
Cell Metab. 2017 Aug 1;26(2):324-341. doi: 10.1016/j.cmet.2017.07.004. Review.
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