Pathways
ChREBP Regulation in Rattus norvegicus
Description:
The liver is the major organ responsible for the conversion of excess dietary carbohydrate into triglycerides. Ins (Insulin) and Glucagon (a pancreatic hormone) play critical roles in homeostatsis of Glucose and triglycerides in humans as well as in R. norvegicus (Rattus norvegicus). Glucose serves as a signal independent of hormones in activation of more than 15 enzyme genes in the lipogenic pathways. However, the mechanism by which Glucose generates signal to induce these gene is not known (Ref.1). Ingestion of a high carbo...
References:
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Regulation of glucose metabolism from a liver-centric perspective.
Exp Mol Med. 2016 Mar 11;48:e218. doi: 10.1038/emm.2015.122. Review. -
ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line.
PLoS One. 2016 Jan 25;11(1):e0147411. doi: 10.1371/journal.pone.0147411. eCollection 2016. -
Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP).
Mol Cell Proteomics. 2017 Jul;16(7):1233-1243. doi: 10.1074/mcp.M116.061416. Epub 2017 Apr 27. -
A novel N-terminal domain may dictate the glucose response of Mondo proteins.
PLoS One. 2012;7(4):e34803. doi: 10.1371/journal.pone.0034803. Epub 2012 Apr 10.
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