Chromatin Remodeling

Description:

The condensation of DNA into an ordered chromatin structure allows the cell to solve the topological problems associated with storing huge molecules of chromosomal DNA within the nucleus. DNA is packaged into chromatin in orderly repeating protein-DNA complexes called nucleosomes. Each nucleosome consists of approximately 146bp of dsDNA (double-stranded DNA) wound 1.8 times around a histone octamer.Two molecules each of H2A, H2B, H3, and H4 comprise the histone ramp around which the DNA superhelix winds. Stretches of DNA upto...

References:

Chromatin dynamics: interplay between remodeling enzymes and histone modifications.
Swygert SG, Peterson CL.
Biochim Biophys Acta. 2014 Aug;1839(8):728-36. doi: 10.1016/j.bbagrm.2014.02.013. Epub 2014 Feb 28. Review.
Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
Cell. 2013 Sep 12;154(6):1207-19. doi: 10.1016/j.cell.2013.08.016.
A rationale to target the SWI/SNF complex for cancer therapy.
Hohmann AF, Vakoc CR.
Trends Genet. 2014 Aug;30(8):356-63. doi: 10.1016/j.tig.2014.05.001. Epub 2014 Jun 3. Review.
Alpha Thalassemia/Mental Retardation Syndrome X-Linked, the Alternative Lengthening of Telomere Phenotype, and Gliomagenesis: Current Understandings and Future Potential.
He J, Mansouri A, Das S.
Front Oncol. 2018 Jan 8;7:322. doi: 10.3389/fonc.2017.00322. eCollection 2017. Review.

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Pathways

Chromatin Remodeling

Description:

References:

Chromatin dynamics: interplay between remodeling enzymes and histone modifications.

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

A rationale to target the SWI/SNF complex for cancer therapy.

Alpha Thalassemia/Mental Retardation Syndrome X-Linked, the Alternative Lengthening of Telomere Phenotype, and Gliomagenesis: Current Understandings and Future Potential.

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Chromatin Remodeling

Description:

References:

Chromatin dynamics: interplay between remodeling enzymes and histone modifications.

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

A rationale to target the SWI/SNF complex for cancer therapy.

Alpha Thalassemia/Mental Retardation Syndrome X-Linked, the Alternative Lengthening of Telomere Phenotype, and Gliomagenesis: Current Understandings and Future Potential.

Databases

Tools

Institutional License

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