Pathways
Cla4-PAK Signaling in Budding Yeast
Description:
Simple eukaryotes such as yeasts and molds encode multiple PAKs (p21-Activated Kinases) that, like their orthologs in other systems, act downstream of Rho-family GTPases to regulate cytoskeletal structure and gene transcription. PAKs are highly conserved effectors of the Rho GTPases CDC42 (Cell Division Cycle-42) and RAC. All PAKs contain an N-terminal PBD (p21 GTPase-Binding-Domain), which confers binding to small GTPases such as CDC42 (Cell Division Cycle-42) or Rac, and a C-terminal protein kinase domain. Three members of ...
References:
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Ste20 and Cla4 modulate the expression of the glycerol biosynthesis enzyme Gpd1 by a novel MAPK-independent pathway.
Biochem Biophys Res Commun. 2019 Oct 1;517(4):611-616. doi: 10.1016/j.bbrc.2019.07.072. -
Architecture, remodeling, and functions of the septin cytoskeleton.
Cytoskeleton (Hoboken). 2019 Jan;76(1):7-14. doi: 10.1002/cm.21475. Epub 2018 Aug 2. -
Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae.
J Cell Biol. 2010 Dec 13;191(6):1097-112. doi: 10.1083/jcb.201005070. -
Response to hyperosmotic stress.
Genetics. 2012 Oct;192(2):289-318. doi: 10.1534/genetics.112.140863.
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