Pathways
Classical Complement Pathway
Description:
Complement is a system of circulating enzymes that is part of the body's response to illness or injury. The complement system plays an essential role in host defence against infectious agents and in the inflammatory process. It consists of about thirty plasma proteins that function either as enzymes or as binding proteins. In addition to these plasma proteins, the complement system includes multiple distinct cell-surface receptors that exhibit specificity for the physiological fragments of complement proteins and that occur on i...
References:
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Complement: structure, functions, evolution, and viral molecular mimicry.
Immunol Res. 2003;27(2-3):367-86. -
C1q, autoimmunity and apoptosis.
Immunobiology. 2002 Sep;205(4-5):395-406. -
On the site of C4 deposition upon complement activation via the mannan-binding lectin pathway or the classical pathway.
Scand J Immunol. 2003 Jun;57(6):556-61. -
Formation of High-affinity C5 Convertase of the Classical Pathway of Complement.
J Biol Chem. 2003 Jul 23.
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