Pathways
Cleavage and Polyadenylation of Pre-mRNA
Description:
During the course of transcription, the initial RNA product synthesized by RNA POL-II (RNA Polymerase-II), called a Primary transcript undergoes several processing steps including Capping, Splicing and Polyadenylation, before a functional mRNA (messenger RNA) is produced. RNA Polymerase initiates transcription at the first nucleotide of the first exon of a gene. Shortly after transcription begins, the 5' end of the nascent RNA is capped with 7-Methyl-Guanylate.Transcription by RNA polymerase-II terminates at any one of th...
References:
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Transcription elongation rate affects nascent histone pre-mRNA folding and 3' end processing.
Genes Dev. 2018 Feb 1;32(3-4):297-308. doi: 10.1101/gad.310896.117. Epub 2018 Feb 26. Erratum in: Genes Dev. 2018 Apr 1;32 (7-8):592. -
Coupling mRNA processing with transcription in time and space.
Nat Rev Genet. 2014 Mar;15(3):163-75. doi: 10.1038/nrg3662. Epub 2014 Feb 11. Review. -
Signals for pre-mRNA cleavage and polyadenylation.
Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):385-96. doi: 10.1002/wrna.116. Epub 2011 Oct 19. Review. -
Ending the message: poly(A) signals then and now.
Genes Dev. 2011 Sep 1;25(17):1770-82. doi: 10.1101/gad.17268411. Review.
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