Pathways
CMV and MAPK Pathways
Description:
An upregulation of cellular signaling pathways is observed in multiple cell types upon HCMV(human cytomegalovirus) infection, suggesting that a global feature of HCMV infection is the activation of the host cell. HCMV initiates and maintains cellular signaling through a multitiered process that is dependent on a series of events: (1) the viral glycoprotein ligand interacts with its cognate receptor, (2) cellular enzymes and viral tegument proteins present in the incoming virion are released and (3) a variety of viral gene pro...
References:
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Human cytomegalovirus modulation of signal transduction.
Curr Top Microbiol Immunol. 2008;325:205-20. Review. -
CMV promoter is repressed by p53 and activated by JNK pathway.
Plasmid. 2013 May;69(3):223-30. doi: 10.1016/j.plasmid.2013.01.004. Epub 2013 Feb 1. -
Modulation of the NFκb Signalling Pathway by Human Cytomegalovirus.
Virology (Hyderabad). 2017 Aug;1(1). pii: 104. Epub 2017 Jul 31. -
New cell-signaling pathways for controlling cytomegalovirus replication.
Am J Transplant. 2014 Jun;14(6):1249-58. doi: 10.1111/ajt.12725. Epub 2014 May 19. Review.
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