Pathways
CNTF Signaling
Description:
CNTF (Ciliary Neurotrophic Factor) is a protein expressed in glial cells, which stimulates gene expression and cell survival and differentiation in a variety of neuronal cell populations and acts as a lesion factor involved in the prevention of nerve degeneration after injury. It is a member of the IL6ST (130-kDa Glycoprotein) cytokine family along with structurally related hemato- and neuropoietic cytokines IL-6 (Interleukin-6), IL-11 (Interleukin-11), LIF (Leukemia Inhibitory Factor), OSM (OncoSOAT1in M), CT-1 (Cardiotrophin-1...
References:
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The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo.
PLoS One. 2013 Apr 23;8(4):e61616. doi: 10.1371/journal.pone.0061616. Print 2013. -
CNTF and retina.
Prog Retin Eye Res. 2012 Mar;31(2):136-51. doi: 10.1016/j.preteyeres.2011.11.005. Epub 2011 Dec 10. Review. -
Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia.
J Neuroinflammation. 2009 Mar 6;6:7. doi: 10.1186/1742-2094-6-7. -
The ERK Cascade: Distinct Functions within Various Subcellular Organelles
Genes Cancer. 2011 Mar; 2(3): 195–209. doi: 10.1177/1947601911407328
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