Pathways
Cocaine Abuse Sigma-1 Receptor
Description:
Drug addiction is considered as a chronic and relapsing psychiatric disorder induced by repeated pharmacological manipulation of mesolimbic reward circuitry during drugs of abuse. It is observe as maladaptive neural plasticity that occurs in vulnerable individuals in response to repeated exposure to drugs. Thus, addictive drugs change brain properties that normally permit us to adapt to environmental stimuli. Cocaine affects the cognitive functions of the NAc (Nucleus Accumbens), particularly in relation to actin cycling in s...
References:
-
Cocaine addicted to cytoskeletal change and a fibrosis high.
Cytoskeleton (Hoboken). 2019 Feb;76(2):177-185. doi: 10.1002/cm.21510. Epub 2019 Jan 22. -
Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Front Pharmacol. 2014 Jan 8;4:172. doi: 10.3389/fphar.2013.00172 -
Sigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects.
Adv Pharmacol. 2014;69:323-86. doi: 10.1016/B978-0-12-420118-7.00009-3. -
Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease.
Adv Exp Med Biol. 2017;964:163-175. doi: 10.1007/978-3-319-50174-1_12.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions