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Cocaine-Dependent Behavioural Plasticity Locomotor Sensitization


Drug addiction is considered as a chronic and relapsing psychiatric disorder induced by repeated pharmacological manipulation of the so-called mesolimbic reward circuitry by drugs of abuse. It can be viewed as maladaptive neural plasticity that occurs in vulnerable individuals in response to repeated exposure to drugs. Thus, addictive drugs change brain properties that normally permit us to adapt to environmental stimuli. Behavioral plasticity, including locomotors sensitization and development of drug, is associated with psy...




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