Cocaine-Dependent Behavioural Plasticity Locomotor Sensitization

Description:

Drug addiction is considered as a chronic and relapsing psychiatric disorder induced by repeated pharmacological manipulation of the so-called mesolimbic reward circuitry by drugs of abuse. It can be viewed as maladaptive neural plasticity that occurs in vulnerable individuals in response to repeated exposure to drugs. Thus, addictive drugs change brain properties that normally permit us to adapt to environmental stimuli. Behavioral plasticity, including locomotors sensitization and development of drug, is associated with psy...

References:

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Cahill E, Salery M, Vanhoutte P, Caboche J.
Front Pharmacol. 2014 Jan 8;4:172. doi: 10.3389/fphar.2013.00172.
Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway.
Jiang SZ, Sweat S, Dahlke SP, Loane K, Drossel G, Xu W, Tejeda HA, Gerfen CR, Eiden LE.
J Neurosci. 2021 Jan 27;41(4):711-725. doi: 10.1523/JNEUROSCI.1497-20.2020. Epub 2020 Dec 2.
From Signaling Molecules to Circuits and Behaviors: Cell-Type-Specific Adaptations to Psychostimulant Exposure in the Striatum.
Salery M, Trifilieff P, Caboche J, Vanhoutte P.
Biol Psychiatry. 2020 Jun 1;87(11):944-953. doi: 10.1016/j.biopsych.2019.11.001. Epub 2019 Nov 9.
Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction.
Corominas M, Roncero C, Ribases M, Castells X, Casas M.
Neuropsychobiology. 2007;55(1):2-13. doi: 10.1159/000103570. Epub 2007 Jun 8.

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Pathways

Cocaine-Dependent Behavioural Plasticity Locomotor Sensitization

Description:

References:

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.

Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway.

From Signaling Molecules to Circuits and Behaviors: Cell-Type-Specific Adaptations to Psychostimulant Exposure in the Striatum.

Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction.

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Pathways

Cocaine-Dependent Behavioural Plasticity Locomotor Sensitization

Description:

References:

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.

Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway.

From Signaling Molecules to Circuits and Behaviors: Cell-Type-Specific Adaptations to Psychostimulant Exposure in the Striatum.

Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction.

Databases

Tools

Institutional License

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