Pathways
Colorectal Cancer Metastasis
Description:
Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. Colorectal cancer results from the accumulation of genetic alterations. Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. Several forms of genomic instability are common in colon cancer: MSI (Microsatellite Instability), CIN (Chromosome Instability), and chromosome transloc...
References:
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Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis.
Crit Rev Oncol Hematol. 2013 Jun;86(3):251-77. doi: 10.1016/j.critrevonc.2012.11.009. Epub 2012 Dec 31. Review. -
Genomic instability and colon carcinogenesis: from the perspective of genes.
Front Oncol. 2013 May 21;3:130. doi: 10.3389/fonc.2013.00130. eCollection 2013. -
Genetic alterations in colorectal cancer.
Gastrointest Cancer Res. 2012 Jan;5(1):19-27. -
Genetic pathways, prevention, and treatment of sporadic colorectal cancer.
Oncoscience. 2014 Jun 30;1(6):400-6. eCollection 2014. Review.
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