Pathways
Crosstalk Between CARM1 and ESRs
Description:
The ESRs (Estrogen Receptors) are ligand-dependent transcription factors and are important Nuclear Hormone Receptors that act as regulators of cell growth, differentiation and malignant transformation. Transcriptional activation by ESRs is accomplished through specific and general cofactor complexes that assemble with the receptor at target promoters to regulate transcription. The chief ligand for ESR is the ovarian steroid hormone Estrogen, which has a primary role in the establishment and maintenance of reproductive function (...
References:
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Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function.
Endocrinology. 2014 Nov;155(11):4461-72. doi: 10.1210/en.2014-1270. Epub 2014 Jul 22. -
Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus.
J Biomed Biotechnol. 2010;2010:317452. doi: 10.1155/2010/317452. Epub 2010 Jun 10. Review. -
Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.
MolEndocrinol. 2003 Oct;17(10):1901-9. Epub 2003 Jul 31. Review. -
Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptionalenhancement.
J Biol Chem. 2002 Oct 4;277(40):37037-44. Epub 2002 Jul 22.
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