CTL Mediated Apoptosis

Description:

The CTLs (Cytotoxic T Lymphocytes), also known as killer T-Cells are produced during cell-mediated immunity designed to remove body cells displaying "foreign" epitope, such as virus-infected cells, cells containing intracellular bacteria, and cancer cells with mutant surface proteins. The CTLs are able to kill these cells by inducing a programmed cell death known as apoptosis (Ref.1).

CTLs only respond to foreign antigen when it is presented bound to the MHC-I (Major Histocompatibility Complex Class-I) expressed on the su...

References:

Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.
Li J, Figueira SK, Vrazo AC, Binkowski BF, Butler BL, Tabata Y, Filipovich A, Jordan MB, Risma KA.
J Immunol. 2014 Jul 15;193(2):519-28. doi: 10.4049/jimmunol.1301668. Epub 2014 Jun 13.
Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo.
Janssen EM, Lemmens EE, Gour N, Reboulet RA, Green DR, Schoenberger SP, Pinkoski MJ.
Immunol Cell Biol. 2010 Oct;88(7):761-5. doi: 10.1038/icb.2010.37. Epub 2010 Mar 23.
How Do Cytotoxic Lymphocytes Kill Cancer Cells?
Martínez-Lostao L, Anel A, Pardo J.
Clin Cancer Res. 2015 Nov 15;21(22):5047-56. doi: 10.1158/1078-0432.CCR-15-0685. Review.
Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable.
Hassin D, Garber OG, Meiraz A, Schiffenbauer YS, Berke G.
Immunology. 2011 Jun;133(2):190-6. doi: 10.1111/j.1365-2567.2011.03426.x. Epub 2011 Mar 29.

You can view details of this pathway by subscribing:

Subscribe Now

Pathways

CTL Mediated Apoptosis

Description:

References:

Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.

Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo.

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable.

Databases

Tools

Institutional License

Pathways

CTL Mediated Apoptosis

Description:

References:

Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.

Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo.

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable.

Databases

Tools

Institutional License

Log In