CTLA4 Signaling

Description:

CTLA4 (CD152) is a member of a class of cell surface molecules capable of terminating early events in the receptor-mediated signaling cascade. It is a 41–43 kDa,type 1 transmembrane glycoprotein of the immunoglobin superfamily having 223 amino acids in length. The extracellular architecture of CTLA4 is characterized by a single IgV-like domain containing the B7- 1 (CD80)/B7-2 (CD86) ligand-binding site. Expression of CTLA4 is dependent both on TCR stimulation by the antigens and CD28-B7 engagement. The costimulatory CTLA4 path...

References:

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/?B7 family.
Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA.
Immunol Rev. 2011 May;241(1):180-205.
CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity.
Herrmann A, Lahtz C, Nagao T, Song JY, Chan WC, Lee H, Yue C, Look T, Mülfarth R, Li W, Jenkins K, Williams J, Budde LE, Forman S, Kwak L, Blankenstein T, Yu H.
Cancer Res. 2017 Sep 15;77(18):5118-5128. doi: 10.1158/0008-5472.CAN-16-0342. Epub 2017 Jul 17.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Nirschl CJ, Drake CG.
Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18. Review.
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.
Holt MP, Punkosdy GA, Glass DD, Shevach EM.
J Immunol. 2017 Feb 15;198(4):1503-1511. doi: 10.4049/jimmunol.1601670. Epub 2017 Jan 4.

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Pathways

CTLA4 Signaling

Description:

References:

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/?B7 family.

CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity.

Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.

TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.

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Tools

Institutional License

Pathways

CTLA4 Signaling

Description:

References:

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/?B7 family.

CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity.

Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.

TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.

Databases

Tools

Institutional License

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