Pathways
Cushing Syndrome
Description:
Cushing’s syndrome (CS) has been described for about a century and represents a classical syndrome in endocrinology. Recent years have been marked by progress in elucidating the etiology and the pathogenesis of the disease. Endogenous Cushing’s syndrome is classically divided into corticotrophin (ACTH)-dependent and ACTH-independent hypercortisolism. ACTH-dependent subtype is caused by a pituitary ACTH-producing adenoma, also known as Cushing’s disease (70% of endogenous Cushing’s syndrome). Other c...
References:
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Genetics of Cushing's syndrome.
Neuroendocrinology. 2010;92 Suppl 1:6-10. doi: 10.1159/000314215. Epub 2010 Sep 10. Review. -
Clinicopathological correlates of adrenal Cushing's syndrome.
J Clin Pathol. 2015 Mar;68(3):175-86. doi: 10.1136/jclinpath-2014-202612. Epub 2014 Nov 25. Review. -
Recent advances in understanding Cushing Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations.
F1000Res. 2017 May 2;6:613. doi: 10.12688/f1000research.10968.1. eCollection 2017. Review. -
Pathophysiology of dyslipidemia in Cushing's syndrome.
Neuroendocrinology. 2010;92 Suppl 1:86-90. doi: 10.1159/000314213. Epub 2010 Sep 10. Review.
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