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Pathways

CXCR4 Pathway

Description:

The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF1) also known as CXCL12. Classically, two alternatively spliced isoforms of SDF have been identified. SDF1Alpha is an 89 amino acid protein that is the predominantly expressed form of SDF1 while SDF1Beta contains a four amino acid extension at the carboxyl terminus. Recently, an additional four splice variants that contain 30 (SDF1Gamma), 31 (SDF1Delta), 1 (SDF1Epsilon), and 51 (SDF1ph...

References:

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