Pathways
CXCR4 Pathway
Description:
The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF1) also known as CXCL12. Classically, two alternatively spliced isoforms of SDF have been identified. SDF1Alpha is an 89 amino acid protein that is the predominantly expressed form of SDF1 while SDF1Beta contains a four amino acid extension at the carboxyl terminus. Recently, an additional four splice variants that contain 30 (SDF1Gamma), 31 (SDF1Delta), 1 (SDF1Epsilon), and 51 (SDF1ph...
References:
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Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration.
Sci Rep. 2015 Nov 18;5:16813. doi: 10.1038/srep16813. -
Phospholipase C-β in immune cells.
Adv Biol Regul. 2013 Sep;53(3):249-57. doi: 10.1016/j.jbior.2013.08.001. Epub 2013 Aug 14. Review. -
SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways.
Sci Rep. 2017 Jan 9;7:40161. doi: 10.1038/srep40161. -
Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.
Front Immunol. 2015 Aug 21;6:429. doi: 10.3389/fimmu.2015.00429. eCollection 2015. Review.
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