Pathways
Cyclins and Cell Cycle Regulation
Description:
Progress in the eukaryotic cell cycle is driven by oscillations in the activities of CDKs (Cyclin-Dependent Kinases). CDK activity is controlled by periodic synthesis and degradation of positive regulatory subunits, Cyclins, as well as by fluctuations in levels of negative regulators, by CKIs (CDK Inhibitors), and by reversible phosphorylation. The mammalian cell cycle consists of four discrete phases: S-phase, in which DNA is replicated; M-phase, in which the chromosomes are separated over two new nuclei in the process of mi...
References:
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Linking cyclins to transcriptional control.
Gene. 2002 Oct 16;299(1-2):35-55. -
A study on the prognostic value of cyclins D1 and E expression levels in resectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes.
J Exp Clin Cancer Res. 2005 Sep; 24(3):405-14. -
Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins.
J Biol Chem. 2002 Sep 20; 277(38): 35140-9. -
Distinct roles for cyclins E and A during DNA replication complex assembly and activation.
Nat Cell Biol. 2002 Jul; 4(7): 523-8.
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