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Pathways

Development of Chronic Lymphocytic Leukemia (CLL)

Description:

Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow in which the bone marrow makes too many lymphocytes. This is a type of slow-growing leukaemia that affects developing B-lymphocytes. CLL is a malignancy of mature CD5+ B-cells that is characterized by apoptosis resistance and dysfunctional immune system. Within a complex cellular network in bone marrow and secondary lymphoid organs (SLOs), T-cel[...]

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