Pathways
Developmental Phases of Colorectal Cancer
Description:
Colorectal tumors arise as a result of the mutational activation of oncogenes coupled with the mutational inactivation of tumor suppressor genes without a major role for gene amplification or rearrangement. These tumors affect the colon and rectum, and most colorectal cancers arise from adenomatous polyps. The development of colorectal neoplasms is characterized by an ordered series of events that are referred to as the “Dysplasia-Carcinoma Sequence” or “Adenoma-Carcinoma Sequence”. Mutations in at lea...
References:
-
The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy.
Oncol Lett. 2018 Jul;16(1):9-18. doi: 10.3892/ol.2018.8679. Epub 2018 May 9. Review. -
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention.
Int J Mol Sci. 2013 Aug 7;14(8):16365-85. doi: 10.3390/ijms140816365. Review. -
Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
Dtsch Arztebl Int. 2013 Jan;110(3):32-8. doi: 10.3238/arztebl.2013.0032. Epub 2013 Jan 18. Review. -
Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk?
World J Gastroenterol. 2012 Aug 7;18(29):3839-48. doi: 10.3748/wjg.v18.i29.3839. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions