Pathways
DNA Methylation and Transcriptional Repression
Description:
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological processes including the silencing of transposable elements, regulation of gene expression, genomic imprinting, and X-chromosome inactivation.DNA methylation of gene promoter regions is associated with transcription repression.Transcriptional repression is an essential mechanism in the precise control of gene expression. Transcriptional repressor proteins associate with their target genes either directly...
References:
-
DNA methylation in mammals.
Cold Spring Harb Perspect Biol. 2014 May 1;6(5):a019133. doi: 10.1101/cshperspect.a019133. Review. -
Repression: targeting the heart of the matter.
Cell. 1999 Nov 24;99(5):455-8. Review. No abstract available. -
DNA methylation and its basic function.
Neuropsychopharmacology. 2013 Jan;38(1):23-38. doi: 10.1038/npp.2012.112. Epub 2012 Jul 11. Review. -
Long Interspersed Element-1 Methylation Level as a Prognostic Biomarker in Gastrointestinal Cancers.
Digestion. 2018;97(1):26-30. doi: 10.1159/000484104. Epub 2018 Feb 1. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions