Pathways
DNA Repair Mechanisms
Description:
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents that result from either endogenous sources (cellular metabolic processes) or exogenous sources (environmental factors). Endogenous sources of DNA damage include hydrolysis, oxidation, alkylation, and mismatch of DNA bases; sources for exogenous DNA damage include ionizing radiation (IR), ultraviolet (UV) radiation, and various chemicals agents (Ref.1). Repairing damage in DNA from anything that causes a mutation, such as UV radia...
References:
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Mechanisms of DNA damage, repair, and mutagenesis.
Environ Mol Mutagen. 2017 Jun;58(5):235-263. doi: 10.1002/em.22087. Epub 2017 May 9. Review. -
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.
Genetics. 2013 Apr;193(4):1025-64. doi: 10.1534/genetics.112.145219. Review. -
Base excision repair.
Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a012583. doi: 10.1101/cshperspect.a012583. Review. -
Review of poly (ADP- ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Crit Rev Eukaryot Gene Expr. 2014;24(1):15-28. Review.
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