Pathways
Dopamine-DARPP32 Feedback onto cAMP Pathway
Description:
One of the ultimate frontiers for mankind is the elucidation of the function of the mind. Dopaminergic and Glutamergic are two primary neurotransmitter systems in the brain, which are crucially important for the control of the body musculature and the Dopamine-induced signaling pathways. Dopamine, a derivative of the amino acid Tyrosine, is a monoamine neurotransmitter that serves as a chemical messenger in the nervous system. It is the predominant Catecholamine neurotransmitter in the mammalian brain, where it controls funct...
References:
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Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMPproduction.
J Neuroimmunol. 2015 Jul 15;284:18-29. doi: 10.1016/j.jneuroim.2015.05.003. Epub 2015 May 1. -
Immunomodulatory Effects Mediated by Dopamine.
J Immunol Res. 2016;2016:3160486. Epub 2016 Oct 4. Review. -
Dopamine signaling in reward-related behaviors.
Front Neural Circuits. 2013 Oct 11;7:152. doi: 10.3389/fncir.2013.00152. eCollection 2013. Review. -
The involvement of DARPP-32 in the pathophysiology of schizophrenia.
Oncotarget. 2017 Apr 21;8(32):53791-53803. doi: 10.18632/oncotarget.17339. eCollection 2017 Aug 8. Review.
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