Pathways
DR3 Signaling
Description:
The TNFR (Tumor Necrosis Factor Receptor) superfamily comprises a growing family of type I membrane bound glycoproteins, which interact with the TNF family of soluble mediators and type II transmembrane proteins. At least 23 TNFR superfamily members and 17 known ligands have been identified in mammals. These receptors trigger pleiotropic responses, ranging from apoptosis and differentiation to proliferation, and have been implicated in immune regulation, host defense and lymphoid organ development. Members of the TNFR family ...
References:
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Membrane trafficking of death receptors: implications on signalling.
Int J Mol Sci. 2013 Jul 11;14(7):14475-503. doi: 10.3390/ijms140714475. Review. -
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4? and CD8? T- cell immunity.
FASEB J. 2012 Aug;26(8):3575-86. doi: 10.1096/fj.11-200618. Epub 2012 May 16. -
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
J Immunol. 2011 May 1;186(9):5212-6. doi: 10.4049/jimmunol.1002374. Epub 2011 Mar 18. -
Death receptor 3 mediates necroptotic cell death.
Cell Mol Life Sci. 2017 Feb;74(3):543-554. doi: 10.1007/s00018-016-2355-2. Epub 2016 Sep 3.
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