DREAM Repression and Dynorphin Expression

Description:

The experience of pain in response to noxious stimuli serves a crucial biological purpose: it alerts a living organism to environmental dangers, inducing behavioral responses that protect the organism from further damage. In contrast, chronic pain arising from disease states and/or pathological functioning of the nervous system offers no advantage and may be debilitating to those afflicted. Control and treatment of chronic pain remain major clinical challenges. The calcium-sensing protein DREAM (Downstream Regulatory Element ...

References:

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
Ramachandran PL, Craig TA, Atanasova EA, Cui G, Owen BA, Bergen HR 3rd, Mer G, Kumar R.
J Biol Chem. 2012 Nov 16;287(47):39439-48. doi: 10.1074/jbc.M112.398495. Epub 2012 Sep 27.
DREAM plays an important role in platelet activation and thrombogenesis.
Kim K, Tseng A, Barazia A, Italiano JE, Cho J.
Blood. 2017 Jan 12;129(2):209-225. doi: 10.1182/blood-2016-07-724419. Epub 2016 Nov 30.
DREAM controls the on/off switch of specific activity-dependent transcription pathways.
Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, Jefferys JG, Bliss TV, Dierssen M, Naranjo JR.
Mol Cell Biol. 2014 Mar;34(5):877-87. doi: 10.1128/MCB.00360-13. Epub 2013 Dec 23.
Does the kappa opioid receptor system contribute to pain aversion?
Cahill CM, Taylor AM, Cook C, Ong E, Morón JA, Evans CJ.
Front Pharmacol. 2014 Nov 17;5:253. doi: 10.3389/fphar.2014.00253. eCollection 2014. Review.

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Pathways

DREAM Repression and Dynorphin Expression

Description:

References:

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

DREAM plays an important role in platelet activation and thrombogenesis.

DREAM controls the on/off switch of specific activity-dependent transcription pathways.

Does the kappa opioid receptor system contribute to pain aversion?

Databases

Tools

Institutional License

Pathways

DREAM Repression and Dynorphin Expression

Description:

References:

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

DREAM plays an important role in platelet activation and thrombogenesis.

DREAM controls the on/off switch of specific activity-dependent transcription pathways.

Does the kappa opioid receptor system contribute to pain aversion?

Databases

Tools

Institutional License

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