Pathways
Drosophila PI3K Pathway
Description:
The PI3K (Phosphatidylinositde-3 Kinase) family of enzymes is recruited upon growth factor receptor activation and produces 3' phosphoinositide lipids. The lipid products of PI3K act as second messengers by binding to and activating diverse cellular target proteins. Therefore, PI3Ks play a central role in many cellular functions. In mammals, the PI3Ks have a p110 catalytic subunit associated with a p85, p55 or p50 regulatory subunit (Ref.1). In Drosophila, the dPI3K (Phosphatidylinositde-3 Kinase) regulatory subunit dp...
References:
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PI3K isoforms in cell signalling and vesicle trafficking.
Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534. doi: 10.1038/s41580-019-0129-z. Review. -
The Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In Vivo.
PLoS One. 2015 May 29;10(5):e0127497. doi: 10.1371/journal.pone.0127497. eCollection 2015. -
Molecular mechanism of size control in development and human diseases.
Cell Res. 2011 May;21(5):715-29. doi: 10.1038/cr.2011.63. Epub 2011 Apr 12. -
A Genetic Screen in Drosophila To Identify Novel Regulation of Cell Growth by Phosphoinositide Signaling.
G3 (Bethesda). 2020 Jan 7;10(1):57-67. doi: 10.1534/g3.119.400851.
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