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DSB Repair by Homologous Recombination


Cellular DNA is constantly exposed to the effects of endogenous or environmental agents such as free radicals, radiation and chemicals. In higher organisms, these nucleic alterations are estimated at several thousands of lesions per cell which can correspond to the loss of bases and also to the breaking of one or both strands of the DNA double helix. Among these DNA breaks, the DSB(double-strand break) is the most harmful because it is the most difficult to repair. DSBs are the most genotoxic DNA lesions.Unrepaired DSBs can...




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