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DSB Repair by Non-Homologous End Joining


DNA double-strand breaks (DSBs) are serious lesions that threaten a loss of chromosomal content. Repair of DSBs is particularly challenging because, unlike all other lesions, the DNA substrate is inherently bimolecular. Bringing two DNA molecules together is also dangerous because local mutations and chromosome rearrangements can arise if ends are inappropriately coupled. The cell has two general strategies for repairing DSBs i.e. HR (Homologous recombination) and NHEJ (Non-homologous end joining). HR is a mechanism in which ...




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