Pathways
Ebola Virus Pathogenesis
Description:
Ebola virus is an aggressive pathogen that causes a highly lethal hemorrhagic fever syndrome in humans and nonhuman primates. Typically, Ebola virus infection runs its course within 14 to 21 days. Infection initially presents with nonspecific flu-like symptoms such as fever, myalgia, and malaise. As the infection progresses, patients exhibit severe bleeding and coagulation abnormalities, including gastrointestinal bleeding, rash, and a range of hematological irregularities, such as lymphopenia and neutrophilia. Cytokines are ...
References:
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Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus.
Cell Rep. 2017 Apr 11;19(2):413-424. doi: 10.1016/j.celrep.2017.03.049. -
Understanding bleeding in ebola virus disease.
Clin Adv Hematol Oncol. 2015 Jan;13(1):29-31. No abstract available. -
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7987-E7996. doi: 10.1073/pnas.1708052114. Epub 2017 Sep 5. -
Graphene-VP40 interactions and potential disruption of the Ebola virus matrix.
Biochem Biophys Res Commun. 2017 Nov 4;493(1):176-181. doi:10.1016/j.bbrc.2017.09.052. Epub 2017 Sep 13.
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