Pathways
EGF Pathway
Description:
Angiogenesis, the growth of new blood vessels, plays a key role in many physiological and pathological processes, such as ovulation, embryogenesis, wound repair, inflammation, malignant tumor growth, retinopathies, rheumatoid arthritis, and angiogenesis-dependent diseases. One of the best-characterized modulators of angiogenesis is the heparin-binding FGF (Fibroblast Growth Factor) (Ref. 1).
FGFs are a large family of multifunctional peptide growth factors of which there are at least 28 distinct members. The member...
References:
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A review on angiogenesis and its assays.
Iran J Basic Med Sci. 2012 Nov;15(6):1110-26. -
Fibroblast growth factor (FGF) signaling in development and skeletal diseases.
Genes Dis. 2014 Dec 1;1(2):199-213. -
Acidic and basic fibroblast growth factors involved in cardiac angiogenesis following infarction.
Int J Cardiol. 2011 Nov 3;152(3):307-13. doi: 10.1016/j.ijcard.2010.07.024. Epub 2010 Aug 2. -
Functional Characterization of VEGF- and FGF-induced Tumor Blood Vessel Models in Human Cancer Xenografts.
Anticancer Res. 2017 Dec;37(12):6629-6638.
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