Pathways
EIF2 Pathway
Description:
Protein synthesis in eukaryotic organisms is a complex process that requires cooperation among a large number of polypeptides including ribosomal proteins, modification of enzymes, and ribosome-associated translation factors. The initiation phase of protein synthesis, during which ribosomes select mRNAs to be translated and identify the translational start site, requires a set of eIFs (eukaryotic Translation Initiation Factors), many of which are comprised of multiple polypeptide subunits. EIF2 (Eukaryotic Initiation Factor-2...
References:
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The mechanism of eukaryotic translation initiation and principles of its regulation.
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838. Review. -
eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics.
Cell Discov. 2015 Aug 11;1:15020. doi: 10.1038/celldisc.2015.20. eCollection 2015. -
Phosphorylation of the translation initiation factor eIF2a at serine 51 determines the cell fate decisions of Akt in response to oxidative stress.
Cell Death Dis. 2015 Jan 15;6:e1591. doi: 10.1038/cddis.2014.554. -
Could the eIF2a-Independent Translation Be the Achilles Heel of Cancer?
Front Oncol. 2015 Nov 26;5:264. doi: 10.3389/fonc.2015.00264. eCollection 2015. Review.
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