Pathways
Endocytic Trafficking of EGFR
Description:
All cells need to interpret their environment. Efficient processing of signals from the extracellular milieu is achieved through dynamic signal-transduction systems. The components of this system that come into contact first with external signals are cell-surface receptors. RTKs (Receptor Tyrosine Kinases) comprise one large group of receptors that respond to polypeptide growth factors and have intrinsic tyrosine kinase activity. On ligand binding, receptor signaling is activated. The activation of RTKs initiates signal transduc...
References:
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The EGFR odyssey - from activation to destruction in space and time.
J Cell Sci. 2017 Dec 15;130(24):4087-4096. doi: 10.1242/jcs.209197. Epub 2017 Nov 27. Review. -
Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures.
Methods Mol Biol. 2017;1652:191-225. doi: 10.1007/978-1-4939-7219-7_15. -
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.
J Cell Biol. 2010 May 31;189(5):871-83. doi: 10.1083/jcb.201001008. -
Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium.
Mol Biol Cell. 2017 Oct 15;28(21):2802-2818. doi: 10.1091/mbc.E16-12-0871. Epub 2017 Aug 16.
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