Pathways
eNOS Signaling
Description:
NO (Nitric Oxide) is a short-lived free radical gas involved in diverse physiological and pathological processes. It is produced along with L-Citrulline by the oxidation of L-Arginine and catalyzed by three different isoforms of NOS (NO Synthase). Type-I nNOS (neuronal NOS) and Type-III eNOS (endothelial NOS) are constitutively expressed as latent enzymes and require a higher concentration of Ca2+ for the enzyme activity. In contrast, Type-II iNOS (inducible NOS) is Ca2+ independent because it’s high affinity for Ca2+/Calm (Ca...
References:
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Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases.
Front Physiol. 2016 Jun 2;7:206. doi: 10.3389/fphys.2016.00206. eCollection 2016. Review. -
Molecular mechanisms of endothelial NO synthase uncoupling.
Curr Pharm Des. 2014;20(22):3548-53. Review. -
Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.
Mol Biol Cell. 2018 May 15;29(10):1190-1202. doi: 10.1091/mbc.E17-01-0049. Epub 2018 Mar 22. -
Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium.
Front Physiol. 2013 Dec 13;4:347. doi: 10.3389/fphys.2013.00347. Review.
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