Pathways
Enteropathogenic E. coli Induced Diarrhea
Description:
Pathogenic microbes subvert normal host-cell processes to create a specialized niche, which enhances their survival. A common and recurring target of pathogens is the host cell's cytoskeleton, which is utilized by these microbes for purposes that include attachment, entry into cells, movement within and between cells, vacuole formation and remodeling, and avoidance of phagocytosis. One such subversive microbe is a gram-negative pathogen EPEC (Enteropathogenic Escherichia coli) that causes chronic, watery diarrhea in humans, prim...
References:
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Diarrheagenic Escherichia coli.
Braz J Microbiol. 2016 Dec;47 Suppl 1:3-30. doi: 10.1016/j.bjm.2016.10.015. Epub 2016 Nov 5. Review. -
Recent advances in understanding enteric pathogenic Escherichia coli.
Clin Microbiol Rev. 2013 Oct;26(4):822-80. doi: 10.1128/CMR.00022-13. Review. -
Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli.
PLoS Pathog. 2018 Aug 17;14(8):e1007224. doi: 10.1371/journal.ppat.1007224. eCollection 2018 Aug. -
Actin cytoskeleton manipulation by effector proteins secreted by diarrheagenic Escherichia coli pathotypes.
Biomed Res Int. 2013;2013:374395. doi: 10.1155/2013/374395. Epub 2012 Dec 30. Review.
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