Pathways
EPHB-EphrinB Signaling
Description:
The Eph family forms the largest group of RTKs (Receptor Tyrosine Kinases) comprising 14 members in mammals that play critical roles in diverse biological processes during development as well as in the mature animal. They are activated by membrane-bound ligands called Ephrins, which are classified into two subclasses based on their mode of membrane anchorage. The Ephrin-A ligands are GPI (Glycosylphosphatidylinositol)-linked and prefer to bind to EphA Receptors. The Ephrin-B ligands (Ephrin-B1–B3), which possess a trans...
References:
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Eph receptor signaling and ephrins.
Cold Spring HarbPerspect Biol. 2013 Sep 1;5(9). pii: a009159. doi: 10.1101/cshperspect.a009159. Review. -
Architecture of Eph receptor clusters.
ProcNatlAcadSci U S A. 2010 Jun 15;107(24):10860-5. doi: 10.1073/pnas.1004148107. Epub 2010 May 26. -
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.
Adv Drug Deliv Rev. 2011 Jul 18;63(8):610-5. doi: 10.1016/j.addr.2010.11.001. Epub 2010 Nov 29. Review. -
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.
Neuron. 2003 Jan 23; 37(2):263-74.
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