Pathways
Ephrin-EPH Signaling
Description:
In numerous processes that are vital for the development and maintenance of organism function, cells must communicate crucial information to respond appropriately to the changing environment. As such, RTKs (Receptor Tyrosine Kinases) are transmembrane proteins, which, on receiving an external stimulus, respond by transmitting a signal to the inside of the cell. Of all the RTKs that are found in the human genome, the Eph Receptor family and their ligands the Ephrins, constitutes the largest family.
The Eph family of...
References:
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Eph receptor signaling and ephrins.
Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a009159. doi: 10.1101/cshperspect.a009159. Review. -
Regulation and misregulation of Eph/ephrin expression.
Cell Adh Migr. 2012 Mar-Apr;6(2):131-7. doi: 10.4161/cam.19690. Epub 2012 Mar 1. Review. -
Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.
Neuron. 2001 Jan; 29(1):73-84. -
Approaches of targeting Rho GTPases in cancer drug discovery.
Expert Opin Drug Discov. 2015;10(9):991-1010. doi: 10.1517/17460441.2015.1058775. Epub 2015 Jun 18. Review.
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