Pathways
EphrinA-EPHR Signaling
Description:
Neuronal growth cones in the developing nervous system are guided to their targets by attractive and repulsive guidance molecules, which include members of the netrin, semaphorin, ephrin, and Slit protein families. The Eph family forms the largest group of RTKs (Receptor Tyrosine Kinases) comprising 14 members in mammals that play critical roles in diverse biological processes during development as well as in the mature animal. They are activated by membrane-bound ligands called Ephrins, which are classified into two subclass...
References:
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Signaling from axon guidance receptors.
Cold Spring Harb Perspect Biol. 2010 May;2(5):a001941. doi: 10.1101/cshperspect.a001941. Epub 2010 Mar 24. Review. -
Control of cell behaviour by signalling through Eph receptors and ephrins.
CurrOpinNeurobiol. 2000 Jun; 10(3):400-8. Review. -
Role of receptor tyrosine kinases and their ligands in glioblastoma.
Cells. 2014 Apr 4;3(2):199-235. doi: 10.3390/cells3020199. -
Control of synapse development and plasticity by Rho GTPase regulatory proteins.
ProgNeurobiol. 2011 Jul;94(2):133-48. doi: 10.1016/j.pneurobio.2011.04.011. Epub 2011 Apr 22. Review.
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