Pathways
Epithelial Adherens Junctions
Description:
Adhesion between neighboring epithelial cells is a crucial and tightly controlled process. The integrity of cell-cell contacts is essential for the regulation of electrolyte absorption and for the prevention of tumor metastasis. In polarized epithelia, specialized structures such as Adherens Junctions (AJs) and Tight Junctions (TJs) are responsible for the establishment of contacts between neighboring cells. The establishment and stability of Adherens Junction is tightly regulated-in particular, by Growth Factors, cytokines a...
References:
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Phosphatase regulation of intercellular junctions.
Tissue Barriers. 2013 Dec 1;1(5):e26713. doi: 10.4161/tisb.26713. Epub 2013 Oct 10. Review. -
Cadherin controls nectin recruitment into adherens junctions by remodeling the actin cytoskeleton.
J Cell Sci. 2015 Jan 1;128(1):140-9. doi: 10.1242/jcs.161588. Epub 2014 Nov 13. -
Interplay between tight junctions & adherens junctions.
Exp Cell Res. 2017 Sep 1;358(1):39-44. doi: 10.1016/j.yexcr.2017.03.061. Epub 2017 Mar 31. Review. -
Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(6):621-9. Review.
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