Pathways
ER-Mediated Phagocytosis
Description:
Phagocytosis, defined as the cellular uptake of particulates (>0.5 m) within a plasma-membrane envelope, is closely related to and partly overlaps the endocytosis of soluble ligands by fluid-phase macropinocytic and receptor pathways. The uptake of exogenous particles (heterophagy) has features in common with autophagy, an endogenous process of sequestration and lysosomal disposal of damaged intracellular organelles. There is a spectrum of uptake mechanisms depending on the particle size, multiplicity of receptor-ligand interact...
References:
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Phagocytosis: An Immunobiologic Process.
Immunity. 2016 Mar 15; 44(3):463-475. doi: 10.1016/j.immuni.2016.02.026. Review. -
Phagocytosis: A Fundamental Process in Immunity.
Biomed Res Int. 2017; 2017:9042851. doi: 10.1155/2017/9042851. Epub 2017 Jun 12. Review. -
Intracellular assembly and trafficking of MHC class I molecules.
Traffic. 2009 Dec; 10(12):1745-52. doi: 10.1111/j.1600-0854.2009.00979.x. Epub 2009 Sep 2. Review. -
Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells.
Nat Immunol. 2005 Jan; 6(1):107-13. Epub 2004 Dec 12.
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