Pathways
ERBB2-ERBB3 Heterodimers
Description:
The ERBB (Erythroblastic Leukemia Viral Oncogene Homolog) family of transmembrane RTKs (Receptor Tyrosine Kinases) plays an important role in the pathogenesis of many cancers. This family is comprised of four members EGFR (Epidermal Growth Factor Receptor), ERBB2, ERBB3, and ERBB4, ERBB2 also called HER2 (Heregulin-2) and ERBB3 are closely related to the EGFR/ERBB1, but unlike EGFR, ERBB2 is a ligandless receptor, whereas ERBB3 lacks tyrosine kinase activity. Hence, both ERBB2 and ERBB3 are active only in the context of ERBB ...
References:
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Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Cancers (Basel). 2017 May 17; 9(5). pii: E52. doi: 10.3390/cancers9050052. Review. -
Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.
J Cell Sci. 2015 Dec 1; 128(23):4306-16. doi: 10.1242/jcs.176933. Epub 2015 Oct 21. -
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.
Nat Rev Cancer. 2009 Jul; 9(7):463-75. doi: 10.1038/nrc2656. Epub 2009 Jun 18. Review. -
The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal nichesof the adult mammalian brain.
Front Cell Neurosci. 2013 Dec 17; 7:258. doi: 10.3389/fncel.2013.00258. Review.
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