Pathways
ERBB4 Pathway
Description:
ERBB4 (Erythroblastic Leukemia Viral Oncogene Homolog-4) is a 180-kDa transmembrane RTK (Receptor Tyrosine Kinase) that regulates cell proliferation and differentiation. The ERBB4 is a member of the EGFR (epidermal growth factor receptor) subfamily of transmembrane RTKs. ERBB4 is expressed in several tissues, mainly heart, mammary gland and the central nervous system. ERBB4 and its ligands have important roles in normal cardiovascular and neural development, differentiation of the mammary gland, and in pathological conditions...
References:
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Function of ERBB4 is determined by alternative splicing.
Cell Cycle. 2011 Aug 15; 10(16):2647-57. Epub 2011 Aug 15. Review. -
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Sci Rep. 2017 Jul 27; 7(1):6747. doi: 10.1038/s41598-017-06439-x. -
The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain.
Front Cell Neurosci. 2013 Dec 17; 7:258. doi: 10.3389/fncel.2013.00258. Review. -
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Cancers (Basel). 2017 May 17; 9(5). pii: E52. doi: 10.3390/cancers9050052. Review.
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