Pathways
ERK Signaling
Description:
The MAPK (Mitogen-Activated Protein Kinase) pathway is one of the primordial signaling systems that nature has used in several permutations to accomplish an amazing variety of tasks. It exists in all eukaryotes, and controls such fundamental cellular processes as Proliferation, Differentiation, Survival and Apoptosis. Mammalian MAPK can be divided into four groups based on their structure and function: ERKs (Extracellular signal-Regulated Kinases), p38MAPKs, JNKs (c-Jun NH2-terminal Kinases) and ERK5 (Extracellular signal-Regula...
References:
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Mitogen-activated protein kinases and their role in radiation response.
Genes Cancer. 2013 Sep;4(9-10):401-8. doi: 10.1177/1947601913485414. Review. -
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.
Physiol Rev. 2010 Oct;90(4):1507-46. doi: 10.1152/physrev.00054.2009. Review. -
GPCR screening via ERK 1/2: a novel platform for screening G protein-coupled receptors.
J Biomol Screen. 2005 Oct;10(7):730-7. Epub 2005 Aug 29. -
Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics.
Gene. 2015 Oct 10;570(2):157-67. doi: 10.1016/j.gene.2015.06.063. Epub 2015 Jun 26. Review.
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