Pathways
ERK5 Signaling
Description:
ERK5 (also known as the BMK1 (Big MAP Kinase-1)) is an atypical MAPK that can be activated in vivo by a variety of stimuli, including Serum, Growth factors including EGF (Epidermal Growth Factor), NGF (Nerve Growth Factor) and BDNF (Brain-Derived Neurotrophic Factor), GPCRs (G-Protein Coupled Receptors), Lysophosphatidic Acid, Neurotrophins and Phorbol ester and some Cellular stress such as Oxidative and Osmotic Shock. MAPK (Mitogen Activated Protein Kinase) cascades play important roles in many cellular processes including c...
References:
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ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.
J Biol Chem. 2009 Aug 28;284(35):23564-73. doi: 10.1074/jbc.M109.027821. Epub 2009 Jul 6. -
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83. doi: 10.1128/MMBR.00031-10. Review. Erratum in: Microbiol Mol Biol Rev. 2012 Jun;76(2):496. -
Use of inhibitors in the study of MAP kinases.
Methods Mol Biol. 2010;661:107-22. doi: 10.1007/978-1-60761-795-2_6. -
ERK5 and Cell Proliferation: Nuclear Localization Is What Matters.
Front Cell Dev Biol. 2016 Sep 22;4:105. eCollection 2016. Review.
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