Pathways
Erythrocyte Invasion by Plasmodium Merozoite
Description:
Malaria is caused by infection with four species of the intracellular protozoan parasite Plasmodium that are transmitted by Anopheles mosquitoes. Most severe form of malaria in human is caused by Plasmodium falciparum, with above 300 million people affected by malaria each year and about 2 million deaths (Ref.1). Life cycle of Plasmodium in human starts with a bite from an infected mosquito and an initial phase of infection and replication in liver cells: the exo-erythrocytic phase, where merozoites are formed. These mer...
References:
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Invasion of red blood cells by malaria parasites.
Cell. 2006 Feb 24;124(4):755-66. Review. -
Host-parasite interactions that guide red blood cell invasion by malaria parasites.
Curr Opin Hematol. 2015 May;22(3):220-6. doi: 10.1097/MOH.0000000000000135. Review. -
Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage.
Front Immunol. 2017 Mar 28;8:349. doi: 10.3389/fimmu.2017.00349. eCollection 2017. Review. -
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3439-3444. doi: 10.1073/pnas.1619441114. Epub 2017 Mar 14.
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