Pathways
Estrogen-mediated S-Phase Entry
Description:
Estrogens are a class of steroid hormones that play a central role in reproduction, and are regarded as the powerful female hormones that make a girl develop into a woman capable of reproduction. Estrogenic steroids, that include: E1 (Estrone), E2 (Estradiol/17-beta Estradiol) and E3 (Estriol), regulate cellular functions in a wide variety of tissues and influence proliferation in the female reproductive tract and mammary gland. It is this proliferative role of these hormones that, a woman's risk for breast and uterine ca...
References:
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Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function.
Mol Cell Biol. 2001 Feb;21(3):794-810. -
New role for estrogen in cancer?
Science. 1998 Mar 13;279(5357):1631-3. No abstract available. Erratum in: Science 1998 Jun 26;280(5372):2033. -
Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta.
EMBO J. 1999 Aug 2;18(15):4270-9. -
Mechanisms of estrogen action.
Physiol Rev. 2001 Oct;81(4):1535-65. Review.
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