Pathways
Exo-Erythrocytic Phase of Malaria Parasite
Description:
Malaria (from the Italian mal'aria, meaning bad air) is an Acute infection caused by four species of the Protozoa genus Plasmodium: P.falciprium, P.vivax, P.malariae and P.ovale. Plasmodium falciparum is the main cause of disease and death from Malaria. The parasite is transmitted to Humans through the bite of the infected female Anopheles Mosquito. Life cycle of Plasmodium inside Human body can be broadly classified into 2 phases: Pre/ Exo-Erythro...
References:
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Malaria.
Adv Exp Med Biol. 2004;549:125-34. -
The Plasmodium sporozoite journey: a rite of passage.
Trends Parasitol. 2003 Mar;19(3):135-43. Review. -
An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion.
J Biol Chem. 2005 Mar 21; [Epub ahead of print] -
The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion.
J Exp Med. 2005 Jan 3;201(1):27-33.
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